Prostaglandin E2

无

A primary COX product of arachidonic acid

PGE2 is one of the primary COX products of arachidonic acid (Item No. 90010) and one of the most widely investigated prostaglandins. Its activity influences inflammation, fertility and parturition, gastric mucosal integrity, and immune modulation.1,2,3,4 The effects of PGE2 are transduced by at least four distinct receptors designated EP1, EP2, EP3, and EP4.5 Affinity constants (Kd) of PGE2 for these receptors range from 1-10 nM depending on the receptor subtype and tissue.

352.5

≥98%

9-氧代-11α，15S-二羟基-丙-5Z，13E-二烯-1-羧酸≥98%杂质≤2%

Dinoprostone|PGE2

O=C1[C@H](C/C=C\CCCC(O)=O)[C@@H](/C=C/[C@@H](O)CCCCC)[C@H](O)C1

C20H32O5

363-24-6

≥ 4 years

DMF: >100 mg/ml DMSO: >100 mg/ml Ethanol: >100 mg/ml PBS (pH 7.2): 5 mg/ml

1.Willis, A.L. and Cornelsen, M. Repeated injection of prostaglandin E₂ in rat paws induces chronic swelling and a marked decrease in pain threshold. Prostaglandins 3, 353-357 (1973).
2.Jackson, G.M.,Sharp, H.T. and Varner, M.W. Cervical ripening before induction of labor: A randomized trial of prostaglandin E₂ gel versus low-dose oxytocin. American Journal of Obstetics and Gynecology 171, 1092-1096 (1994).
3.Robert, A.,Schultz, J.R.,Nezamis, J.E., et al. Gastric antisecretory and antiulcer properties of PGE₂, 15-methyl PGE₂, and 16,16-dimethyl PGE₂. Intravenous, oral and intrajejunal administration. Gastroenterology 70, 359-370 (1976).
4.Arvind, P.,Papavassiliou, E.D.,Tsioulias, G.J., et al. Prostaglandin E₂ down-regulates the expression of HLA-DR antigen in human colon adenocarcinoma cell lines. Biochemistry 34, 5604-5609 (1995).
5.Coleman, R.A.,Smith, W.L. and Narumiya, S. Classification of prostanoid receptors: Properties, distribution, and structure of the receptors and their subtypes. Pharmacological Reviews 46, 205-229 (1994).