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BVT 14225
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产品介绍
产品介绍
产品信息
简单描述
BVT 14225 is an inhibitor of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1; IC50s = 52 and 284 nM for the human and mouse enzymes, respectively).1 It is selective for human 11β-HSD1 over human 11β-HSD2 (IC50 = >10,000 nM). It inhibits 11β-HSD1 by 55% in HEK293 cells expressing human HSD11B1, the gene encoding 11β-HSD1, when used at a concentration of 10 µM.2 BVT 14225 (50 mg/kg) reduces blood glucose levels in a rat model of diabetes induced by streptozotocin (Item No. 13104) and nicotinamide (Item No. 11127).WARNING This product is not for human or veterinary use.
商品描述
An 11β-HSD1 inhibitor
分子量
401.9
纯度
≥98%
产品类型
Biochemicals/Small Molecule Inhibitors/Sterol Biosynthesis
背景
别名
Formal_Name:2-[[(3-chloro-2-methylphenyl)sulfonyl]amino]-N,N-diethyl-4-thiazoleacetamide
研究领域
Endocrinology & Metabolism/Hormones & Receptors/Glucocorticoids & Mineralocorticoids/Metabolic Diseases/Diabetes,Lipid Biochemistry/Sterol Lipids
结构式
ClC1=C(C)C(S(NC2=NC(CC(N(CC)CC)=O)=CS2)(=O)=O)=CC=C1
分子式
C16H20ClN3O3S2
CAS号
376638-65-2
制备和贮存
保存
≥ 4 years
溶解方法
DMSO: Sparingly soluble: 1-10 mg/ml
保存方式
-20°C
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