全部商品分类
用小程序，查商品更便捷
产品介绍
产品介绍
产品信息
抗原名称
CDK, Cyclin
产品特色
Protect from light. Packaged under inert gas.
商品描述
CDK/cyclin inhibitor
Cell permeable, potent, selective and ATP-competitive inhibitor of CDK2/cyclin A (IC50=22nM), CDK1/cyclin B (IC50=40nM) and CDK4/cyclin D1 (IC50=200nM). Has no effect on the activity of PKC, p38, PDGFRβ and EGFR (IC50>10µM). Displays anti-proliferative and pro-apoptotic properties in tumor cells. Inhibits proliferation of growth factor-stimulated colon carcinoma cells by binding to CDK2 and thus preventing the phosphorylation of pRb and its dissociation from E2F.
分子量
241.3
化学式
C13H11N3O2
纯度
≥95% (HPLC)
可溶性
Soluble in DMSO (10mg/ml).
外观
Yellow to orange solid.
产品类型
Inhibitor
背景
别名
3-[1-(3H-Imidazol-4-yl)-meth-(Z)-ylidene]-5-methoxy-1,3-dihydro-indol-2-one
分子式
C13H11N3O2
CAS号
377090-84-1
制备和贮存
保存
As indicated on product label or CoA when stored as recommended.
保存方式
运输条件:Blue Ice
Long Term Storage:+4°C
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。