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产品介绍
产品介绍
产品信息
简单描述
Flavokawain A is a chalcone that has been found in P. methysticum and has diverse biological activities.1,2,3 It activates nuclear factor erythroid 2-related factor 2 (Nrf2) and heat shock factor 1 (Hsf1; EC50s = 14.1 and 7.9 µM, respectively, in reporter assays), increases glutathione (GSH) levels, and protects against hydrogen peroxide-induced cytotoxicity in HepG2 cells.1 Flavokawain A (10 and 20 µM) inhibits LPS-induced increases in inducible nitric oxide synthase (iNOS), COX-2, nitric oxide (NO), and prostaglandin E2 (PGE2; Item No. 14010) levels in RAW 264.7 macrophages.2 It induces apoptosis in T24 bladder cancer cells when used at a concentration of 12.5 µg/ml.3 Flavokawain A (50 mg/kg) reduces tumor growth in an EJ bladder cancer mouse xenograft model.WARNING This product is not for human or veterinary use.
商品描述
A chalcone with diverse biological activities
分子量
314.3
纯度
≥98%
产品类型
Biochemicals/Antioxidants/Small Molecule Activators/Transcription Factors & Coactivators,Natural Products/Chalcones
背景
别名
Formal_Name:(2E)-1-(2-hydroxy-4,6-dimethoxyphenyl)-3-(4-methoxyphenyl)-2-propen-1-one;Synonyms:Flavokavain A 4-methoxy Flavokawain B
研究领域
Cancer/Cell Death/Apoptosis/Transcription Factors,Cell Biology/Cell Signaling/Nitric Oxide Signaling,Epigenetics, Transcription, & Translation/Transcription Factors,Immunology & Inflammation/Inflammatory Lipid Mediators/Prostaglandins/Innate Immunity,Oxidative Stress & Reactive Species/Antioxidant Activity/Reactive Sulfur/Glutathione
结构式
COC1=C(C(O)=CC(OC)=C1)C(/C=C/C2=CC=C(C=C2)OC)=O
分子式
C18H18O5
CAS号
37951-13-6
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 5 mg/ml
DMSO: 2 mg/ml
保存方式
-20°C
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