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产品介绍
产品介绍
产品信息
商品描述
4-Amino-1,8-naphthalimide is a small molecule inhibitor of PARP-1 (poly (ADP-ribose) polymerase-1), an enzyme responsible for mediating covalent attachment of residues to proteins. Inhibition of this enzyme can sensitize cells to the cytotoxicity of chemical agents, and can also decrease cell death related to reperfusion and ischemia-related oxygen free radicals by attenuating the rapid depletion of cellular NAD and ATP resulting from excessive activation of PARP.
分子量
212.2
纯度
≥96%
可溶性
Soluble in DMSO (5 mg/ml).
IC50
Poly (ADP-ribose) polymerase-1 (PARP-1): IC50 = 0.18 µM
应用
实验应用
A PARP-1 inhibitor
背景
别名
4-氨基-1,8-萘二酰亚胺
分子式
C12H8N2O2
CAS号
1742-95-6
EC号码
217-110-1
沸点
~544.07° C at 760 mmHg (Predicted)
MDL
MFCD00006921
PK值
pKa: 9.53, pKb: 1.54
密度
1.11 g/cm3 at 25° C (lit.)
折射率
n20D 1.77
制备和贮存
保存方式
Store at room temperature
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