Sirtinol

Selective sirtuin inhibitor which does not effect HDAC1 (IC₅₀ = 131 M, 38 M and 68 M for SIRT1, SIRT2 and Sir2P respectively) (ref 1). Induces apoptotic and autophagic cell death in MCF-7 human breast cancer cell lines (ref 2). Suppresses survivin expression which correlates with decreased viability in HT29 colon cancer cells (ref 3). Displays pro-inflammatory effects in adipocytes (ref 4).

394.5

>98% (TLC); NMR (Conforms)

Yellow powder. May be dissolved in DMSO (35 mg/ml); Ethanol (10 mg/ml).

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2-[(2-Hydroxynaphthalen-1-ylmethylene)amino]-N-(1-phenethyl)benzamide

C₂₆H₂₂N₂O2