Polymyxin B1

The polymyxins are cationic peptides originally isolated from B. polymyxa.1 They bind and kill Gram-negative bacteria.2 The B series of polymyxins consist of a cyclic heptapeptide and a tripeptide side chain acylated at the amino terminus by a fatty acid. Polymyxin B1 is a form of polymyxin B which terminates with 6-methyloctanamide. Polymyxin B1 is comparable to other B polymyxins in its ability to kill P. aeruginosa, A. baumannii, and K. pneumoniae isolates.3 Its relative pharmacokinetics and nephrotoxicity have not been examined.WARNING This product is not for human or veterinary use.

A cationic peptide antibiotic

1203.5

≥95%

Biochemicals/Antibiotics/Polypeptides/Peptides,Natural Products/Microbial Metabolites

Formal_Name:(S)-N-((S)-4-amino-1-(((2S,3R)-1-(((S)-4-amino-1-oxo-1-(((3S,6S,9S,12S,15R,18S,21S)-6,9,18-tris(2-aminoethyl)-15-benzyl-3-((R)-1-hydroxyethyl)-12-isobutyl-2,5,8,11,14,17,20-heptaoxo-1,4,7,10,13,16,19-heptaazacyclotricosan-21-yl)amino)butan-2-yl)amino)-3-hydroxy-1-oxobutan-2-yl)amino)-1-oxobutan-2-yl)-6-methyloctanamide

O=C([C@@H](NC([C@H](CCN)NC(CCCC[C@@H](C)CC)=O)=O)[C@@H](C)O)N[C@@H](CCN)C(N[C@@H](CCNC([C@@H](NC([C@

C56H98N16O13

4135-11-9

≥ 4 years

1N HCl: 10 mg/ml

1.Falagas, M.E. and Kasiakou, S.K. Toxicity of polymyxins: A systematic review of the evidence from old and recent studies. Critical Care 10(1), (2006).
2.Hancock, R.E.W. Cationic peptides: Effectors in innate immunity and novel antimicrobials. Lancet Infect.Dis. 1(3), 156-164 (2001).
3.Tam, V.H.,Cao, H.,Ledesma, K.R., et al. In vitro potency of various polymyxin B components. Antimicrobial Agents and Chemotherapy 55(9), 4490-4491 (2011).