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产品介绍
产品信息
简单描述
PGH2 (Prostaglandin H2), a precursor for the 2-series thromboxanes and prostaglandins, is a potent platelet aggregator of vascular smooth muscle contraction. PGH2 is also an inhibitor of platelet TXA synthase (thromboxane synthase). In the rabbit pulmonary artery PGH2 activated the stretch induced contraction of rabbit pulmonary artery. At an IC50 at 10-25 ng/ml in the isolated rat fat cell PGH2 inhibited the accumulation of noradrenaline induced cyclic AMP.
参考文献 1. Hamberg, M., et al. 1974. Proc. Natl. Acad. Sci. U.S.A. 71: 345-349. PMID: 4521806 2. Brothers, T.E., et al. 1998. J. Vasc. Surg. 27: 317-25. PMID: 9510286 3. Saito, M., et al. 2003. Eur. J. Pharmacol. 467: 151-161. PMID: 12706469
分子量
352.50
纯度
95%
组合货号
干冰
应用
实验应用
PGH2 (Prostaglandin H2), 1 mg/500 µl is a thromboxane A2 precursor and a platelet aggregator of vascular smooth muscle contraction
背景
结构式
CCCCC[C@@H](/C=C/[C@H]1[C@H]2C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)OO2)O
分子式
C20H32O5
CAS号
42935-17-1
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