Asiatic Acid

A natural triterpene with diverse beneficial effects

Asiatic acid is a pentacyclic triterpene isolated from a variety of plants, including C. asiatica, used in traditional medicines. In addition to anti-inflammatory actions, asiatic acid stimulates wound healing by increasing collagen production.1 It has also been found to induce cell cycle arrest and apoptosis in breast cancer cells (IC50 = 5.9 µM for MCF-7 cells) and block angiogenesis in cells and tumors from glioblastomas.2,3 Asiatic acid also impacts amyloid-β precursor protein processing by down regulating BACE1 while increasing ADAM10 maturation in primary rat cortical neurons.4 In addition, it reduces neuronal damage and cognitive defects resulting from glutamate administration in vivo in mice while demonstrating protective effects against glutamate-induced apoptosis in isolated SH-SY5Y cells.5

488.7

≥95%

Dammarolic Acid|NSC 166063

OC[C@]1(C)[C@@H](O)[C@H](O)C[C@@]2(C)[C@@]1([H])CC[C@]3(C)[C@]2([H])CC=C4[C@@]3(C)CC[C@]5(C(O)=O)[C@@]4([H])[C@@H](C)[C@H](C)CC5

C30H48O5

464-92-6

≥ 4 years

DMF: 20 mg/ml DMSO: 20 mg/ml DMSO:PBS(pH 7.2) (1:3): 0.25 mg/ml Ethanol: 10 mg/ml

1.Maquart, F.X.,Chastang, F.,Simeon, A., et al. Triterpenes from Centella asiatica stimulate extracellular matrix accumulation in rat experimental wounds. Eur.J.Dermatol. 9(4), 289-296 (1999).
2.Hsu, Y.L.,Kuo, P.L.,Lin, L.T., et al. Asiatic acid, a triterpene, induces apoptosis and cell cycle arrest through activation of extracellular signal-regulated kinase and p38 mitogen-activated protein kinase pathways in human breast cancer cells. Journal of Pharmacology and Experimental Therapeutics 313(1), 333-344 (2005).
3.Kavitha, C.V.,Agarwal, C.,Agarwal, R., et al. Asiatic acid inhibits pro-angiogenic effects of VEGF and human gliomas in endothelial cell culture models. PLoS One 6(8), (2011).
4.Patil, S.P.,Maki, S.,Khedkar, S.A., et al. Withanolide A and asiatic acid modulate multiple targets associated with amyloid-β precursor protein processing and amyloid-β protein clearance. Journal of Natural Products 73(7), 1196-1202 (2010).
5.Xu, M.F.,Xiong, Y.Y.,Liu, J.K., et al. Asiatic acid, a pentacyclic triterpene in Centella asiatica, attenuates glutamate-induced cognitive deficits in mice and apoptosis in SH-SY5Y cells. Acta.Pharmacol.Sin. 33, 578-587 (2012).