Benzoylaconine

Benzoylaconine is an aconitine-type diterpenoid alkaloid that has been found in Aconitum species.1,2 Benzoylaconine increases protein levels of the efflux transporters P-glycoprotein, multidrug resistance-associated protein 2 (MRP2), and breast cancer resistance protein (BCRP) in LS174T cells in a concentration-dependent manner.2,3 It also increases the protein levels of P-glycoprotein in Caco-2 cells and the pregnane X receptor (PXR) in both Caco-2 and LS174T cells when used at a concentration of 50 μM.3 Benzoylaconine (50 μM) reduces the cytotoxic effects of the P-glycoprotein substrates vincristine (Item No. 11764) and doxorubicin (Item No. 15007) in Caco-2 cells. In vivo, benzoylaconine (0.6 mg/kg) increases protein levels of Nrf2, MRP2, and BCRP in the jejunum, ileum, and colon in mice.2 It also increases survival of mice injected with a lethal dose of the neurotoxin aconitine (ED50 = 15 mg/kg, i.p.).1WARNING This product is not for human or veterinary use.

An aconitine-type diterpenoid alkaloid

603.7

≥95%

Biochemicals,Lipids/Prenol Lipids,Natural Products/Alkaloids/Terpenes

Formal_Name:(1α,3α,6α,14α,15α,16β)-20-ethyl-1,6,16-trimethoxy-4-(methoxymethyl)-aconitane-3,8,13,14,15-pentol, 14-benzoate

CO[C@@H]1C2(C3N4CC)[C@@]([C@@H](OC)C3[C@]([C@@H](O)[C@H](OC)[C@]5(O)[C@@H]6OC(C7=CC=CC=C7)=O)(O)[C@]

C32H45NO10

466-24-0

≥ 4 years

DMF: 25 mg/ml DMSO: 20 mg/ml Ethanol: 25 mg/ml PBS (pH 7.2): 10 mg/ml