490 MMP FRET Substrate X 1 mg

Matrix Metalloproteinase (MMP)

Matrix Metalloproteinases (MMPs) are a large family of endopeptidases. Collectively, MMPs can degrade all kinds of extracellular matrix proteins, and can also process a number of bioactive molecules. They are known to be involved in the cleavage of cell surface receptors, the release of apoptotic ligands, and chemokine/cytokine inactivation. MMPs are also thought to play a major role in cell behaviors such as cell proliferation, migration (adhesion/dispersion), differentiation, angiogenesis, apoptosis, and host defense.This peptide has an optimized sequence for MMP-7, with the cleavage occuring at the Ala-Leu bond. The substrate is used for high throughput screening of MMP-7 inhibitors. Abs/Em = 340/490 nm.

Sequence code:DABCYL-RPLALWRS-EDANS;Sequence three code:DABCYL-Arg-Pro-Leu-Ala-Leu-Trp-Arg-Ser-EDANS

1497.8

Peak Area by HPLC ≥95%

Lyophilized

Fluorescent;FRET,Protease activity

C73H100N20O13S