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4E2RCat
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产品介绍
产品介绍
产品信息
抗原名称
Eukaryotic Initiation Factor (eIF)
商品描述
4E2RCat is an inhibitor of eIF4E-eIF4G interaction with an IC50 of 13.5 μM.
分子量
455.93
纯度
98%
可溶性
DMSO : 23.33 mg/mL (51.17 mM; Need ultrasonic)
In vitro(体外研究)
4E2RCat prevents the interaction between eIF4E (the cap-binding protein) and eIF4G (a large scaffolding protein), inhibiting cap-dependent translation. It significantly decreases human coronavirus 229E (HCoV-229E) replication, reducing the percentage of infected cells and intra- and extracellular infectious virus titers. 4E2RCat inhibits cap-dependent translation in a dose-dependent manner. 4E2RCat inhibits cap-dependent FF translation but not EMCV IRES-driven Ren translation. 4E2RCat inhibits coronavirus replication in a dose- and time-dependent manner.
In vivo(体内研究)
4E2RCat inhibits protein synthesis in vivo and it is not a consequence of increased cell death.
背景
分子式
C22H14ClNO4S2
CAS号
432499-63-3
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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