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产品介绍
产品介绍
产品信息
抗原名称
mAChR
商品描述
5-hydroxymethyl tolterodine是一种tolterodine的主要药理活性代谢物。5-hydroxymethyl tolterodine会竞争性抑制carbachol诱导的豚鼠离体膀胱条收缩，这种抑制具有浓度依特性。 5-hydroxymethyl tolterodine拮抗蕈毒碱受体 的pA2值为9.1。
分子量
341.49
纯度
>98%
可溶性
Ethanol ：63 mg/mL (184.5 mM)
DMSO ：63 mg/mL (184.5 mM)
DMSO ：63 mg/mL (184.5 mM)
外观
淡黄色固体
In vitro(体外研究)
5-hydroxymethyl tolterodine is a major pharmacologically active metabolite of tolterodine. 5-hydroxymethyl tolterodine produces a competitive and concentration-dependent inhibition of carbachol-induced contraction of guinea-pig isolated urinary bladder strips. 5-hydroxymethyl tolterodine antagotizes muscarinic receptors with a pA2 of 9.1. 5-hydroxymethyl tolterodine causes a concentration-dependent inhibition of (-)3 H-QNB binding in homogenates of guinea-pig urinary bladder, parotid gland, heart and cerebral cortex. 5-hydroxymethyl tolterodine has a similar pharmacological profile with tolterodine. Intravenous infusion of 5-hydroxymethyl tolterodine produces a dose-dependent inhibition of the intravesical volume-induced urinary bladder contraction measured as the micturition pressure.
In vivo(体内研究)
5-hydroxymethyl tolterodine is significantly more potent at inhibiting acetylcholine-induced urinary bladder contraction than electrically induced salivation in the anaesthetised cat (ID50 15 and 40 nmol/kg, respectively. 5-hydroxymethyl tolterodine is three times more potent at the urinary bladder compared to the salivary gland.
背景
别名
(R)-5-羟甲基托特罗定；Desfesoterodine；PNU-200577
分子式
C22H31NO2
CAS号
207679-81-0
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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