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8-Bromo-cGMP

8-Bromo-cGMP

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品牌: SantaCruz
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分子式:
C10H10BrN5O7P•Na
分子量:
446.08
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产品介绍
产品介绍
产品信息
简单描述
8-Bromo-cGMP is a cell-permeable cGMP analog with greater resistance to hydrolysis by phosphodiesterases than cGMP. The compound has been shown to preferentially activate cGKIα/β (cGMP-dependent protein kinase). In human platelets, 8-Bromo-cGMP has been found to inhibit thrombin stimulated arachidonic acid release. 8-Bromo-cGMP is known to slow or inhibit intracellular calcium oscillations of tracheal smooth muscle cells in response to acetylcholine. 参考文献 1. Meyer, R.B., et al. 1974. Life Sci. 14: 1019-1040. PMID: 4362776 2. Schultz, K.D., et al. 1979. Naunyn Schmiedebergs Arch. Pharmacol. 306: 1-9. PMID: 218117 3. Francis, S.H., et al. 1988. Mol. Pharmacol. 34: 506-517. PMID: 2845250 4. Garg, U.C., et al. 1989. Am. J. Physiol. 257: F60-F66. PMID: 2546445 5. Sane, D.C., et al. 1989. Biochem. Biophys. Res. Commun. 165: 708-714. PMID: 2557018 6. Garg, U.C., et al. 1989. J. Clin. Invest. 83: 1774-1777. PMID: 2540223 7. Prakash, Y.S., et al. 1997. Am. J. Physiol. 272: L588-L596. PMID: 9142929 8. Choi, J., et al. 1998. J. Pharmacol. Exp. Ther. 285: 588-594. PMID: 9580602
分子量
446.08
组成成分
8-溴代鸟苷-3',5'-环状单磷酸酯钠盐≥96%
应用
实验应用
8-Bromo-cGMP is a cell-permeable cGMP analog resistance to hydrolysis than cGMP
背景
别名
8-BR-cGMP sodium salt;8-Bromoguanosine 3′,5′-cyclic monophosphate sodium salt
结构式
C1C2C(C(C(O2)N3C4=C(C(=O)N=C(N4)N)N=C3Br)O)OP(=O)(O1)[O-].[Na+]
分子式
C10H10BrN5O7P•Na
CAS号
51116-01-9
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货号:
sc-200316
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