(d(CH2)51,Tyr(Me)2,A (1 mg)

122173055

YFQNCPRG

(Modifications: Tyr-1 = Pmp-Tyr(Me), Gly-8 = C-terminal amide)

Selective vasopressin V_1A antagonist

1151.38

Selective vasopressin V_1A receptor antagonist. Inhibits vasopressin and oxytocin-induced increases in intracellular calcium concentrations in vitro (IC₅₀ values are 5 and 30 nM respectively). Exhibits potent and prolonged antivasopressor activity and induces anxiolytic-like effects in the dorsal, but not ventral, hippocampus in vivo.

≥95% (HPLC)

Soluble to 2 mg/ml in water

COC1=CC=C(C[C@@H]2NC(=O)CC3(CCCCC3)SSC[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC3

C₅₂H₇₄N₁₄O₁₂S₂

73168-24-8