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5‘-Iodoresiniferatoxin
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产品介绍
产品介绍
产品信息
纯化方式
>99%
抗原名称
TRPV1 channels
来源纯化
Semi-synthetic
商品描述
5'-IRTX;A Potent and Partial Blocker of TRPV1 Channel;5’-Iodoresiniferatoxin (#I-800) is a highly pure, semi-synthetic, and biologically active compound.
分子量
754.6
生物活性
5'-Iodoresiniferatoxin is a potent and partial blocker of TRPV1 (Vanilloid/Capsaicin receptor 1) channel1. It also abolishes the inhibitory effect of capsaicin on CaV currents in DRG neurons2.
纯度
>99%
可溶性
DMSO or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
浓度
100 nM - 10 µM.
形式
Lyophilized
背景
别名
6,7-Deepoxy-6,7-didehydro-5-deoxy-21-dephenyl-21-(pheny lmethyl)-daphnetoxin,20-(4-hydroxy-5-iodo-3-methoxybenzene acetate).
背景
5’-Iodoresiniferatoxin (5’-IRTX) is a potent and partial antagonist of the TRPV1 (Vanilloid/capsaicin receptor) channel.1 It is an iodinated form of the potent agonist Resiniferatoxin (#R-400). 5’-Iodoresiniferatoxin partially blocked capsaicin-induced currents in Xenopus oocytes expressing TRPV1 channels (IC50 = 3.9 nM).1 5’-Iodoresiniferatoxin abolished an inhibitory effect of capsaicin on CaV currents (probably mediated by TRPV1) in DRG neurons.
分子式
C37H39IO9.
CAS号
535974-91-5
制备和贮存
存储溶液
Up to two weeks at 4°C or six months at -20°C.Protect from light.
保存方式
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.;Up to two weeks at 4°C or six months at -20°C.Protect from light.
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