Decamethonium (bromide)

Decamethonium is a depolarizing neuromuscular blocking agent.1 It is a partial agonist of muscle-type nicotinic acetylcholine receptors (nAChRs).2 Decamethonium activates α1β1-containing adult mouse muscle-type nAChRs expressed in X. laevis oocytes with an EC50 value of 40 µM using voltage clamp electrophysiology. It is also a nondepolarizing antagonist of neuronal-type nAChRs, inhibiting mouse α7-, α3β2-, α3β4-, and α4β2-containing receptors with IC50 values of 7.4, 405, 28, and 59 µM, respectively. Decamethonoium is a competitive antagonist of α4β2-containing nAChRs expressed in SH-EP1 cells (IC50 = 52 µM for the human receptor).3 It also inhibits electric eel acetylcholinesterase (AChE) and blocks electrically-evoked tibialis muscle twitches in anesthetized cats with ED95 values of 35 and 70 µg/kg for cats under chloralose and ether anesthesia, respectively.1,4 Formulations containing decamethonium have been used to induce paralysis during anesthesia.WARNING This product is not for human or veterinary use.

A depolarizing neuromuscular blocking agent

418.3

≥98%

Biochemicals/Ion Channel Modulation/Activators/Blockers/Receptor Pharmacology/Agonists/Antagonists/Small Molecule Inhibitors/Acetylcholine Turnover

Formal_Name:N1,N1,N1,N10,N10,N10-hexamethyl-1,10-decanediaminium, dibromide

C[N+](CCCCCCCCCC[N+](C)(C)C)(C)C.[Br-].[Br-]

C16H38N2 • 2Br

541-22-0

≥ 4 years

DMF: 2 mg/ml DMSO: 16 mg/ml Ethanol: 33 mg/ml PBS (pH 7.2): 5 mg/ml

2811