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Resiniferatoxin
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产品介绍
产品介绍
产品信息
抗原名称
TRPV1 channels
来源纯化
Natural
商品描述
Reciniferatoxin, RTX;A Potent and Selective Activator of TRPV1 Channel;Resiniferatoxin (#R-400) is a highly pure, natural, and biologically active compound.
分子量
628.72
生物活性
Resiniferatoxin is a potent and selective activator of the TRPV1 (Vanilloid/Capsaicin receptor 1) channel1.
纯度
95-98% (HPLC)
可溶性
Methanol or ethanol. Centrifuge all product preparations before use (10000 x g 5 min).
浓度
20 nM - 1 µM.
形式
Lyophilized
背景
别名
4-Hydroxy-3-methoxy-[(2S,3aR,3bS,6aR,9aR,9bR,10R,11aR)- 3a,3b,6,6a,9a,10,11,11aoctahydro-6a-hydroxy-8,10-dimethyl-11a-(1-methylethenyl)-7-oxo-2-(phenylmethyl)-7H-2,9 b-epoxyazuleno[5,4-e]-1,3-benzodioxol-5-yl]benzeneaceta.
背景
Resiniferatoxin is a potent and selective agonist of the TRPV1 (Vanilloid/Capsaicin receptor) channel.1 Application of sub-nanomolar concentrations of Resiniferatoxin irreversibly induces a sustained slow current and depolarization in DRG neurons.2
Treatment of rats with Resiniferatoxin, like treatment with capsaicin, causes hypothermia, neurogenic inflammation and pain. These responses were followed by a loss of thermoregulation, by desensitization to neurogenic inflammation and by chemical and thermal analgesia, with a cross-tolerance between Resiniferatoxin and capsaicin.1
分子式
C37H40O9.
CAS号
57444-62-9
制备和贮存
保存方式
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.;Up to two week at 4°C or six months at -20°C.
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