MK-212 (hydrochloride)

MK-212 is an agonist of the serotonin (5-HT) receptor subtype 5-HT2C (EC50 = 0.028 µM in a calcium mobilization assay).1 It is selective for 5-HT2C over 5-HT2A receptors (EC50 = 0.42 µM). MK-212 reduces food intake in fasted rats with an ED50 value of 5 mg/kg.2 It reduces cocaine-primed reinstatement of cocaine-seeking behavior in rats when administered at doses of 0.32, 0.56, or 1 mg/kg.3WARNING This product is not for human or veterinary use.

A 5-HT2C receptor agonist

235.1

≥98%

Biochemicals/Receptor Pharmacology/Agonists

Formal_Name:2-chloro-6-(1-piperazinyl)-pyrazine, monohydrochloride

ClC1=CN=CC(N2CCNCC2)=N1.Cl

C8H11ClN4 • HCl

61655-58-1

≥ 4 years

PBS (pH 7.2): Slightly soluble Water: Slightly soluble

3288