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产品介绍
产品介绍
产品信息
简单描述
MHY553 is an agonist of peroxisome proliferator-activated receptor α (PPARα).1 It activates PPARα in HepG2 cells in a reporter assay when used at a concentration of 1 µM but does not activate PPARβ or PPARγ at 10 µM. MHY553 (3 µM) prevents triglyceride accumulation induced by the liver X receptor (LXR) agonist T0901317 (Item No. 71810) in HepG2 cells, as well as scavenges reactive oxygen species (ROS) and peroxynitrite in cell-free assays (IC50s = 39.7 and 2.39 µM, respectively).1,2 It also inhibits β-glucuronidase and tyrosinase (IC50s = 8.9 and 0.01 µM for the bovine liver and mushroom enzymes, respectively).3,4 MHY553 (5 mg/kg) reduces age-induced increases in liver weight and triglyceride levels in a rat model of hepatic steatosis.1WARNING This product is not for human or veterinary use.
商品描述
An agonist of PPARα
分子量
243.3
纯度
≥98%
产品类型
Biochemicals/Antioxidants/Receptor Pharmacology/Agonists/Small Molecule Inhibitors
背景
别名
Formal_Name:4-(2-benzothiazolyl)-1,3-benzenediol;Synonyms:NSC 33005
研究领域
Endocrinology & Metabolism/Carbohydrate Metabolism/Hormones & Receptors/PPARs/Metabolic Diseases/Steatotic Liver Diseases,Oxidative Stress & Reactive Species/Antioxidant Activity/Reactive Nitrogen/Reactive Oxygen
结构式
OC1=CC(O)=C(C2=NC3=CC=CC=C3S2)C=C1
分子式
C13H9NO2S
CAS号
6265-56-1
制备和贮存
保存
≥ 4 years
溶解方法
DMSO: 24.5 mg/ml
保存方式
-20°C
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