Disuccinimidyl Suberate

Protein cross-linking agent

Disuccinimidyl suberate (DSS) is a bifunctional cross-linking reagent which contains two N-hydroxysuccinimide esters that are reactive toward primary amines. DSS is membrane-permeable and is commonly used to cross-link proteins in intact cells.1,2

368.3

≥98%

DSS|NSC 340008

O=C(CCCCCCC(=O)ON1C(=O)CCC1=O)ON1C(=O)CCC1=O

C16H20N2O8

68528-80-3

≥ 4 years

DMF: 10 mg/ml DMSO: 20 mg/ml DMSO:PBS (pH 7.2)(1:5): 0.15 mg/ml

1.Hétu, P.O.,Ouellet, M.,Falgueyret, J.P., et al. Photo-crosslinking of proteins in intact cells reveals a dimeric structure of cyclooxygenase-2 and an inhibitor-sensitive oligomeric structure of microsomal prostaglandin E₂ synthase-1. Archives of Biochemistry and Biophysics 477, 155-162 (2008).
2.Ding, H., and Johnson, G.V.W. New application of ß-galactosidase complementation to monitor tau self-association. Journal of Neurochemistry 106, 1545-1551 (2008).