Isorhynchophylline

An oxindole alkaloid with diverse biological activities

Isorhynchophylline is an oxindole alkaloid that has been found in Uncaria and has diverse biological activities, including neuroprotective, anticancer, and antihypertensive properties.1,2,3,4 It inhibits decreases in cell viability and increases in intracellular levels of reactive oxygen species (ROS) and malondialdehyde (MDA) induced by amyloid-β (25-35) (Aβ (25-35); Item No. 24155) in PC12 cells in a concentration-dependent manner.1 Isorhynchophylline (30 and 100 μM) attenuates decreases in population spike amplitudes in the CA1 region of a rat hippocampal slice model of ischemia induced by oxygen and D-glucose deprivation.2 It decreases the viability of HepG2, A549, BxPC-3, Caki-1, RPMI-8226, and 786-O cells (IC50s = 130-292 μM).3 In HepG2 cells, isorhynchophylline induces apoptosis, inhibits cell migration in a wound healing assay, and decreases invasion in a Matrigel™ assay. Isorhynchophylline (0.1% in the diet) decreases right ventricular end systolic pressure, hypertrophy, and fibrosis in a rat model of pulmonary arterial hypertension induced by monocrotaline (Item No. 16666).4

384.5

≥95%

(+)-Isorhynchophylline

O=C(OC)/C([C@@H]1[C@@H](CC)CN2[C@@]([C@@]3(C(C=CC=C4)=C4NC3=O)CC2)([H])C1)=C/OC

C22H28N2O4

6859-01-4

≥ 4 years

DMF: 10 mg/ml DMSO: 10 mg/ml DMSO:PBS (pH 7.2) (1:5): 0.16 mg/ml Ethanol: 1 mg/ml

1544