SKF 86002

SKF 86002 is an anti-inflammatory agent.1,2,3,4 It inhibits rat seminal vesicle prostaglandin H2 (PGH2) synthase (IC50 = 120 µM), as well as prostanoid production by rat basophilic leukemia (RBL-1) cells and human monocytes (IC50s = 70 and 1 µM, respectively).1 SKF 86002 inhibits leukotriene B4 (LTB4) and LTC4 production induced by A23187 (Item No. 11016) in human neutrophils and monocytes, respectively (IC50 = 20 µM for both). It also inhibits LPS-induced IL-1 production in human monocytes (IC50 = 1.3 µM).2 SKF 86002 (10, 30, and 90 mg/kg) reduces hindleg volume in rat models of adjuvant- or collagen-induced arthritis.3 It also decreases serum levels of TNF-α and increases survival in a mouse model of LPS and galactosamine-induced endotoxic shock when administered at a dose of 100 mg/kg.4WARNING This product is not for human or veterinary use.

An anti-inflammatory agent

297.4

≥98%

Biochemicals/Small Molecule Inhibitors/Prostaglandin Synthases

Formal_Name:6-(4-fluorophenyl)-2,3-dihydro-5-(4-pyridinyl)-imidazo[2,1-b]thiazole

FC1=CC=C(C2=C(C3=CC=NC=C3)N4C(SCC4)=N2)C=C1

C16H12FN3S

72873-74-6

≥ 4 years