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产品介绍
产品介绍
产品信息
抗原名称
PI3K
序列号
H-Arg-Gln-Ile-Lys-Ile-Trp-Phe-Gln-Asn-Arg-Arg-Met-Lys-Trp-Lys-Lys-Ser-Asp-Gly-Gly-pTyr-Met-Asp-Met-Ser-OH
商品描述
740 Y-P is an activator of PI3K with concentration of 20 μM .
分子量
3270.72
纯度
98%
可溶性
Water ：1 mg/mL (0.31 mM)
外观
White to off-white powder
In vitro(体外研究)
740 Y-P is a synthetic biotinylated peptide consisting of the 16-amino acid sequence derived from the third helix of the Antennapedia protein in tandem with a 9 amino acid phosphopeptide mimetic of the high affinity p85 binding site on the PDGF receptor. 740 Y-P readily binds GST fusion proteins containing both the N- and C- terminal SH2 domains of p85. 740 Y-P fails to bind GST alone, or a GST fusion protein containing the N- terminal SH2 domain of PLCg and shows relatively weak binding of a GST fusion proteins containing the SH2 domain of Grb2. The 740 Y-P peptide is also able to specifically interact with p85 in cell lysates as shown by affinity precipitation. 740 Y-P stimulates mitogenesis at the lowest concentration tested (1 mg/mL). The peptide stimulates mitogenesis in both the presence and absence of serum (0.5%), and in the former instance a maximal response observed at 50 mg/mL. 740Y-P peptide to stimulate mitogenesis is highly specific and not a general feature of a cell permeable SH2 domain binding peptides.
In vivo(体内研究)
740 Y-P is not only internalised in living cells but can also interact with p85 in vivo.
来源（爱必信）
Synthetic
应用
注意事项
该产品以TFA盐的形式提供
背景
别名
PDGFR 740Y-P
分子式
C141H222N43O39PS3
CAS号
1236188-16-1
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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