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Voglibose
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产品介绍
产品介绍
产品信息
简单描述
An α-glucosidase inhibitor
商品描述
Voglibose is an inhibitor of α-glucosidases (IC50s = 5.6, 0.11, 0.16, and 0.07 µM for human lysosomal α-glucosidase and rat maltase, isomaltase, and sucrase, respectively).1 It is selective for human α- over β-glucosidase (IC50 = >1,000 μM). Voglibose (0.2 mg/kg) decreases body weight and food intake in sucrose-loaded Goto-Kakizaki (GK) type 2 diabetic rats.2
分子量
267.3
纯度
≥95%
背景
别名
AO-128
结构式
O[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(O)C[C@@H]1NC(CO)CO
分子式
C10H21NO7
CAS号
83480-29-9
制备和贮存
保存
≥ 4 years
溶解方法
DMSO: 2 mg/mL
PBS (pH 7.2): 5 mg/mL
保存方式
-20°C
文献
文献
1.Dabhi, A.S.,Bhatt, N.R. and Shah, M.J. Voglibose: An alpha glucosidase inhibitor. J.Clin.Diagn.Res. 7(12), 3023-3027 (2013).
2.Kuriyama, C.,Kamiyama, O.,Ikeda, K., et al. In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorganic & Medicinal Chemistry 16(15), 7330-7336 (2008).
3.Natori, Y.,Imahori, T.,Murakami, K., et al. The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry Letters 21(2), 738-741 (2011).
4.Göke, B.,Fuder, H.,Wieckhorst, G., et al. Voglibose (AO-128) is an efficient α-glucosidase inhibitor and mobilizes the endogenous GLP-1 reserve. Digestion 56(6), 493-501 (2016).
5.Nauck, M.A.,Vardarli, I.,Deacon, C.F., et al. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down? Diabetologia 54(1), 10-18 (2011).
6.Standl, E. and Schnell, O. Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation. Diab.Vasc.Dis.Res. 9(3), 163-169 (2012).
2.Kuriyama, C.,Kamiyama, O.,Ikeda, K., et al. In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures. Bioorganic & Medicinal Chemistry 16(15), 7330-7336 (2008).
3.Natori, Y.,Imahori, T.,Murakami, K., et al. The synthesis and biological evaluation of 1-C-alkyl-L-arabinoiminofuranoses, a novel class of α-glucosidase inhibitors. Bioorganic & Medicinal Chemistry Letters 21(2), 738-741 (2011).
4.Göke, B.,Fuder, H.,Wieckhorst, G., et al. Voglibose (AO-128) is an efficient α-glucosidase inhibitor and mobilizes the endogenous GLP-1 reserve. Digestion 56(6), 493-501 (2016).
5.Nauck, M.A.,Vardarli, I.,Deacon, C.F., et al. Secretion of glucagon-like peptide-1 (GLP-1) in type 2 diabetes: What is up, what is down? Diabetologia 54(1), 10-18 (2011).
6.Standl, E. and Schnell, O. Alpha-glucosidase inhibitors 2012 - cardiovascular considerations and trial evaluation. Diab.Vasc.Dis.Res. 9(3), 163-169 (2012).
参考图片
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