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1G244
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产品介绍
产品介绍
产品信息
简单描述
1G244 is an inhibitor of dipeptidyl peptidase 8 (DPP-8) and DPP-9 (IC50s = 14 and 53 nM, respectively).1 It is selective for DPP-8 and DPP-9 over DPP-4, DPP-2, and fibroblast activation protein (FAP; IC50s = >100 µM for all). 1G244 (20 µM) inhibits the differentiation of 3T3-L1 cells into adipocytes.2 It induces caspase-1-dependent pyroptosis in RAW 264.7 macrophages when used at a concentration of 10 µM.3 1G244 (2 mg/kg) decreases atherosclerotic lesion area and M1-like macrophage plaque infiltration in apoE-/- mice in a model of atherosclerosis induced by a high-fat diet.4WARNING This product is not for human or veterinary use.
商品描述
A DPP-8 and DPP-9 inhibitor
分子量
504.6
纯度
≥95%
产品类型
Biochemicals/Small Molecule Inhibitors/Peptidases & Proteases
背景
别名
Formal_Name:2S-amino-4-[4-[bis(4-fluorophenyl)methyl]-1-piperazinyl]-1-(1,3-dihydro-2H-isoindol-2-yl)-1,4-butanedione;Synonyms:PTX1210
研究领域
Cardiovascular System/Cardiovascular Diseases/Atherosclerosis,Cell Biology/Cell Death/Pyroptosis/Proteolysis/Cytosolic & Secreted Proteases,Endocrinology & Metabolism/Metabolic Diseases,Immunology & Inflammation/Innate Immunity
结构式
FC1=CC=C(C(N2CCN(C(C[C@H](N)C(N3CC4=C(C=CC=C4)C3)=O)=O)CC2)C5=CC=C(F)C=C5)C=C1
CAS号
847928-32-9
制备和贮存
保存
≥ 4 years
溶解方法
DMSO: Sparingly soluble: 1-10 mg/ml
Ethanol: Sparingly soluble: 1-10 mg/ml
保存方式
-20°C
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