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Lenvatinib (mesylate)
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产品介绍
产品介绍
产品信息
简单描述
An inhibitor of VEGFR2 and VEGFR3
商品描述
Lenvatinib is an inhibitor of the receptor tyrosine kinases VEGF receptor 2 (VEGFR2) and VEGFR3 (IC50s = 4 and 5.2 nM, respectively).1,2 It also inhibits the related kinases VEGFR1, FGFR1, PDGFRα, PDGFRβ and KIT (IC50s = 22, 46, 51, 39, and 100 nM, respectively).1 Lenvatinib (30 mg/kg, twice per day) reduces tumor growth in an H146 small cell lung cancer mouse xenograft model and induces tumor regression when administered at a dose of 100 mg/kg twice per day. Formulations containing lenvatinib have been used in the treatment of differentiated thyroid cancer, renal cell carcinoma, and hepatocellular carcinoma.
分子量
523
纯度
≥98%
背景
别名
E-7080
结构式
COC(C(C(N)=O)=C1)=CC2=C1C(OC3=CC(Cl)=C(NC(NC4CC4)=O)C=C3)=CC=N2.CS(O)(=O)=O
分子式
C21H19ClN4O4 • CH3SO3H
CAS号
857890-39-2
制备和贮存
保存
≥ 4 years
溶解方法
DMSO: 1mg/mL
DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL
保存方式
-20°C
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