PSNCBAM-1

PSNCBAM-1 is a cannabinoid 1 (CB1) receptor negative allosteric modulator (NAM).1 It is selective for CB1 over CB2 in HEK293 cells expressing the human receptors (IC50s = 74.3 and >10,000 nM, respectively). PSNCBAM-1 inhibits activation of the CB1 receptor induced by (±)-CP 55,940 (Item No. 13241), anandamide (AEA; Item No. 90050), or 2-arachidonoyl glycerol (2-AG; Item No. 62160) in yeast expressing human CB1 (IC50s = 45.2, 37 and 230.3 nM, respectively). It reduces food intake within one hour and decreases body weight in male rats when administered at a dose of 30 mg/kg. PSNCBAM-1 (10 mg/kg) reduces THC-induced increases in tail-flick latency in mice.2WARNING This product is not for human or veterinary use.

A CB1 receptor negative allosteric modulator

392.9

≥98%

Biochemicals/Receptor Pharmacology/Allosteric Modulators

Formal_Name:N-(4-chlorophenyl)-N'-[3-[6-(1-pyrrolidinyl)-2-pyridinyl]phenyl]-urea

ClC1=CC=C(NC(NC2=CC(C3=NC(N4CCCC4)=CC=C3)=CC=C2)=O)C=C1

C22H21ClN4O

877202-74-9

≥ 4 years

DMSO: soluble