GW 9508

GW 9508 is a cell-permeable aminophenylpropanoate that acts as a potent and selective agonist for the G-protein coupled receptor (GPCR) GRP40/FFA1 receptor (EC50 ~ 50 nM) with reduced activity towards family members GRP120 (EC50 3.5 μM), GRP41/GRP43 (EC50 >50 μM), as well as a panel of eight other free fatty acid (FFA) and prostaglandin receptors. GW 9508 has been shown to induce GPR40-dependent Ca2+ mobilization in HEK 293 cells and potentiate glucose-stimulated insulin secretion in MIN6 cells. 参考文献 McKeown, S C., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1584. Briscoe, C. P., et al. 2006. Br. J. Pharmacol. 148, 619.

347.4

powder

GW 9508 is an aminophenylpropanoate agonist at the GRP40/FFA1 receptor

3-(4-(((3-(Phenoxy)phenyl)methyl)amino)phenyl)propanoic acid; GPR40 Agonist

C1=CC=C(C=C1)OC2=CC=CC(=C2)CNC3=CC=C(C=C3)CCC(=O)O

C22H21NO3

885101-89-3