Interleukin-1α (human) ELISA Kit

Interleukin-1 (IL-1) is a name for a family of proteins which include IL-α, IL-1β, ILra (interleukin receptor antagonist), and IL-18. IL-1α is synthesized as a 33 kDa (271 amino acid) pro-cytokine that is enzymatically cleaved by calpain into the active 159 amino acid, 17 kDa peptide.^1,2,3 IL-1α is produced by many cells types including macrophages, monocytes, astrocytes, keratinocytes, adipocytes, T-cells, and eosinophils.⁴ Although IL-1α and IL-1β exhibit only 26% amino acid identity,¹ they bind to the same cell-surface receptors, IL-1 RI and IL-1 RII, present on a variety of cell types involved in immune or inflammatory responses.^5,6,7 Normal production of IL-1 is critical for mediating host responses to infection and injury.^8,9 Disease states in which IL-1 actively participates include inflammatory diseases such as arthritis, inflammatory bowel disease, and shock, as well as atherosclerosis, allergy, and some types of cancer.^8,9 Cayman’s IL-1α (human) ELISA Kit is an immunometric (i.e., sandwich) ELISA that permits IL-1α measurements within the range of 3.9-250 pg/ml, typically with a limit of detection of 3.9 pg/ml.

IL-1α (human) EIA Kit;

89-57-6

≥ 1 year

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