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产品介绍
产品介绍
产品信息
简单描述
Verdiperstat is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 630 nM), a redox enzyme involved in oxidative stress.1 It is selective for MPO over a panel of 130 enzymes, transporters, and ion channels (IC50s = >50 µM for all).2 Oral administration of verdiperstat (180 µmol/kg) reduces MPO expression, prevents an increase in neuronal loss, and prevents decreases in motor score and stride length in a PLP-αSYN transgenic mouse model of multiple system atrophy, a neurological disorder characterized by motor neuron degeneration and α-synuclein aggregation in the brain.2WARNING This product is not for human or veterinary use.
商品描述
An irreversible inhibitor of MPO
分子量
253.3
纯度
≥98%
产品类型
Biochemicals/Small Molecule Inhibitors
背景
别名
Formal_Name:1,2,3,5-tetrahydro-1-[2-(1-methylethoxy)ethyl]-2-thioxo-4H-pyrrolo[3,2-d]pyrimidin-4-one;Synonyms:AZD 3241 BHV 3421
研究领域
Neuroscience/Neurodegenerative Disorders,Oxidative Stress & Reactive Species/Reactive Oxygen/Myeloperoxidase
结构式
O=C1NC(N(CCOC(C)C)C2=C1NC=C2)=S
分子式
C11H15N3O2S
CAS号
890655-80-8
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 10 mg/ml
DMSO: 10 mg/ml
Ethanol: 2 mg/ml
保存方式
-20°C
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