Verdiperstat

An irreversible inhibitor of MPO

Verdiperstat is an irreversible inhibitor of myeloperoxidase (MPO; IC50 = 630 nM), a redox enzyme involved in oxidative stress.1 It is selective for MPO over a panel of 130 enzymes, transporters, and ion channels (IC50s = >50 µM for all).2 Oral administration of verdiperstat (180 µmol/kg) reduces MPO expression, prevents an increase in neuronal loss, and prevents decreases in motor score and stride length in a PLP-αSYN transgenic mouse model of multiple system atrophy, a neurological disorder characterized by motor neuron degeneration and α-synuclein aggregation in the brain.2

253.3

≥98%

AZD 3241|BHV 3421

O=C1NC(N(CCOC(C)C)C2=C1NC=C2)=S

C11H15N3O2S

890655-80-8

≥ 4 years

DMF: 10 mg/ml DMSO: 10 mg/ml Ethanol: 2 mg/ml