Tazobactam

Tazobactam is a β-lactamase inhibitor with greater activity against Ambler class A serine penicillinases and class C cephalosporinases, including TEM-1, SHV-1, and P99 (IC50s = 97, 150, and 8.5 nM, respectively) than class B metallo-β-lactamases and the class D oxacillinase OXA-1 (IC50s = 400,000 and 1,400 nM, respectively).1 However, it also inhibits the class D oxacillinase OXA-2 (IC50 = 10 nM). Tazobactam, in combination with piperacillin, is active against Gram-positive (MIC90s = 2-128 µg/ml) and Gram-negative bacteria (MIC90s = 4-128 µg/ml).2 In a neutropenic mouse model of thigh infection, tazobactam potentiates the activity of ceftolozane against Enterobacteriaceae.3 Formulations containing tazobactam, alone and in combination with piperacillin, have been used in the treatment of β-lacatamase-producing bacteria.WARNING This product is not for human or veterinary use.

A β-lactamase inhibitor

300.3

≥98%

Biochemicals/Antibiotics/Small Molecule Inhibitors

Formal_Name:(2S,3S,5R)-3-methyl-7-oxo-3-(1H-1,2,3-triazol-1-ylmethyl)-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylic acid, 4,4-dioxide;Synonyms:CL-298741 YTR 830H

O=C(C1)N2[C@]1([H])S([C@](CN3C=CN=N3)(C)[C@@H]2C(O)=O)(=O)=O

C10H12N4O5S

89786-04-9

≥ 4 years

DMF: 30 mg/ml DMSO: 30 mg/ml Ethanol: 30 mg/ml PBS (pH 7.2): 5 mg/ml