AMG 1

AMG 1 is an inhibitor of c-Met and Ron (IC50s = 4 and 9 nM, respectively).1 It is selective for c-Met and Ron over seven tyrosine and serine/threonine kinases (IC50s = 160 to 1,900 nM). AMG 1 decreases the levels of phosphorylated MET, ERK1/2, and Akt in HT-29 colon and BxPC-3 pancreatic cancer cells, as well as reduces migration in a wound-healing assay using NIH3T3/TPR-Met fibroblasts, in a concentration-dependent manner. It reduces tumor volume in a U87 glioma mouse xenograft model when administered at a dose of 30 mg/kg twice per day. AMG 1 increases bone volume and bone regrowth area in a mouse model of calvarial defect when administered at a dose of 50 µg in an absorbable collagen sponge.2WARNING This product is not for human or veterinary use.

A c-Met and Ron inhibitor

556.6

≥98%

Biochemicals/Kinase Inhibitors/HGFR Family/Small Molecule Inhibitors/Kinases

Formal_Name:N-[3-fluoro-4-[(7-methoxy-4-quinolinyl)oxy]phenyl]-2,3-dihydro-1-(2-hydroxy-2-methylpropyl)-5-methyl-3-oxo-2-phenyl-1H-pyrazole-4-carboxamide;Synonyms:KIN001-237 KIN237 RON-IN-1 RON Inhibitor 1 SYN1143

OC(C)(C)CN(C(C)=C1C(NC2=CC(F)=C(OC3=C(C=CC(OC)=C4)C4=NC=C3)C=C2)=O)N(C5=CC=CC=C5)C1=O

C31H29FN4O5

913376-84-8

≥ 4 years

DMSO: Soluble: =10 mg/ml