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TG101209
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产品介绍
产品介绍
产品信息
简单描述
An inhibitor of JAK2, FLT3, RET, and JAK3
商品描述
TG101209 is a potent inhibitor of the tyrosine kinases janus kinase (JAK) 2, FMS-like tyrosine kinase 3, proto-oncogene RET, and JAK3 (IC50 = 6, 25, 17, and 169 nM, respectively).1 Through these effects, it induces cell cycle arrest and apoptosis in leukemic cell lines and CD45+ myeloma cells.1,2
分子量
509.7
纯度
≥98%
背景
结构式
CC(C)(C)NS(C1=CC=CC(NC2=NC(NC3=CC=C(N4CCN(C)CC4)C=C3)=NC=C2C)=C1)(=O)=O
分子式
C26H35N7O2S
CAS号
936091-14-4
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 16 mg/ml
DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml
DMSO: 12.5 mg/ml
Ethanol: 0.12 mg/ml
保存方式
-20°C
文献
文献
1.Pardanani, A.,Lasho, T.,Levine, R.L., et al. TG101209, a small molecule JAK2-selective kinase inhibitor potently inhibits myeloproliferative disorder-associated JAK2V617F and MPLW515L/K mutations. Leukemia 21(8), 1658-1668 (2007).
2.Ramakrishnan, V.,Kimlinger, T.,Haug, J., et al. TG101209, a novel JAK2 inhibitor, has significant in-vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells. American Journal of Hematology 85(9), 675-686 (2010).
2.Ramakrishnan, V.,Kimlinger, T.,Haug, J., et al. TG101209, a novel JAK2 inhibitor, has significant in-vitro activity in multiple myeloma and displays preferential cytotoxicity for CD45+ myeloma cells. American Journal of Hematology 85(9), 675-686 (2010).
参考图片
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