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ACTB-1003
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产品介绍
产品介绍
产品信息
简单描述
ACTB-1003 is a multi-kinase inhibitor (IC50s = 6, 2, 4, 5, and 32 nM for FGFR1, VEGFR2, Tie-2, RSK, and p70S6K, respectively).1 It inhibits growth of OPM2 human multiple myeloma and murine Ba/F3-TEL-FGFR1 leukemia cells in vitro. ACTB-1003 inhibits tumor angiogenesis in an H460 mouse xenograft model. It also reduces tumor growth in an HCT116 mouse xenograft model when administered in combination with 5-fluorouracil (5-FU; Item No. 14416) or paclitaxel (Item No. 10461).WARNING This product is not for human or veterinary use.
商品描述
A multi-kinase inhibitor
分子量
591.5
纯度
≥98%
产品类型
Biochemicals/Kinase Inhibitors/Small Molecule Inhibitors/Kinases
背景
别名
Formal_Name:N-[4-[4-amino-6-(methoxymethyl)-7-(4-morpholinylmethyl)pyrrolo[2,1-f][1,2,4]triazin-5-yl]-2-fluorophenyl]-N′-[2-fluoro-5-(trifluoromethyl)phenyl]-urea
研究领域
Cancer/Angiogenesis
结构式
NC1=NC=NN2C1=C(C3=CC(F)=C(NC(NC4=CC(C(F)(F)F)=CC=C4F)=O)C=C3)C(COC)=C2CN5CCOCC5
分子式
C27H26F5N7O3
CAS号
939805-30-8
制备和贮存
保存
≥ 4 years
溶解方法
DMF: 30 mg/ml
DMSO: 30 mg/ml
DMSO:PBS (pH 7.2) (1:2): 0.33 mg/ml
Ethanol: 1 mg/ml
保存方式
-20°C
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