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MJ15
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产品介绍
产品介绍
产品信息
简单描述
A potent CB1 receptor antagonist
商品描述
MJ15 is a potent antagonist of the cannabinoid (CB) receptor CB1 (IC50 = 118.9 pM; Ki = 27.2 pM for rat CB1).1 It is selective for CB1 over CB2, exhibiting only 46% inhibition of CB2 at a concentration of 10 μM. MJ15 reverses (+)-WIN 55,212-2 (Item No. 10009023) inhibition of forskolin-induced cAMP accumulation in a dose-dependent manner in CHO cells expressing human CB1. MJ15 (40 mg/kg) reduces food intake and body weight gain in a rat model of diet-induced obesity. It also reduces body weight gain and white adipose accumulation in a mouse model of early onset diet-induced obesity.
分子量
471.8
纯度
≥98%
背景
结构式
CC1=C(C2=CC=C(Cl)C=C2)N(C3=CC=C(Cl)C=C3Cl)N=C1C(NCC4=CC=CN=C4)=O
分子式
C23H17Cl3N4O
CAS号
944154-76-1
制备和贮存
保存
≥ 4 years
溶解方法
DMSO: <100 mM
Ethanol: slightly soluble
保存方式
-20°C
参考图片
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