全部商品分类首页
A-803467
用小程序，查商品更便捷
产品介绍
产品信息
纯化方式
>99% (HPLC)
抗原名称
NaV1.8 Na+ channels
来源纯化
Synthetic
商品描述
A-803467 (#A-105) is a highly pure, synthetic, and biologically active compound.
分子量
357.8
生物活性
A-803467 is a potent and selective blocker of the TTX-resistant NaV1.8 channel. A-803467 is a state dependent inhibitor with IC50 of 8 nM at depolarized membrane potential (-40 mV) and 80 nM at -100 mV. As an efficient inhibitor of TTX-resistant currents in DRG neurons, A-803467 was also effective as an analgesic in several rodent models of different pathological pain states1,2. A-803467 was used as a pharmacological tool to demonstrate the expression of NaV1.8 in the heart conduction system and its contribution to QRS interval in the mouse heart3.
可溶性
DMSO. Centrifuge all product preparations before use (10000 x g 5 min).
浓度
10 nM - 10 μM.
形式
Lyophilized
背景
分子式
C19H16ClNO4.
CAS号
944261-79-4
制备和贮存
存储溶液
Up to four weeks at 4°C or three months at -20°C.
保存方式
Shipped at room temperature. Product as supplied can be stored intact at room temperature for several weeks. For longer periods, it should be stored at -20°C.
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。