(±)-SDZ-201 106

(±)-SDZ-201 106 is a diphenylpiperazinylindole derivative that prolongs the open state of cardiac voltage-gated Na+ channels. It has been shown to increase net Na+ influx and the activity of reverse mode Na+/Ca2+ exchange, which leads to an increase in intracellular Ca2+, as well as to partially inhibit the Na+ pump in cardiac myocytes.1 (±)-SDZ-201 106 is also reported to act as an open-channel blocker of delayed-rectifier K+ channels in NG108-15 neuronal cells.2WARNING This product is not for human or veterinary use.

A sodium channel opener

466.6

≥98%

Biochemicals/Ion Channel Modulation/Activators/Blockers/Transporter & Exchanger Modulators

Formal_Name:4-[3-[4-(diphenylmethyl)-1-piperazinyl]-2-hydroxypropoxy]-1H-indole-2-carbonitrile;Synonyms:DPI 201-106

OC(COC1=CC=CC2=C1C=C(C#N)N2)CN(CC3)CCN3C(C4=CC=CC=C4)C5=CC=CC=C5

C29H30N4O2

97730-95-5

≥ 4 years

DMF: 30 mg/ml DMSO: 30 mg/ml Ethanol: 1.6 mg/ml

1.Kaumann, A.H.,Richards, D.E., and Russell, D.A. Inhibition of the sodium pump by cardioactive DPI 201-106. Br. J. Pharmacol. 91(1), 3-5 (1987).
2.Wang, Y.-J.,Lin, M.-W.,Lin, A.-A., et al. Evidence for state-dependent block of DPI 201-106, a synthetic inhibitor of Na⁺ channel inactivation, on delayed-rectifier K⁺ current in pituitary tumor (GH3) cells. J. Physiol. Pharmacol. 59(3), 409-423 (2008).