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Emestrin
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产品介绍
产品介绍
产品信息
简单描述
Emestrin is a mycotoxin originally isolated from E. striata that has antimicrobial, immunomodulatory, and cytotoxic activities.1,2,3,4,5 It is active against the fungi C. albicans and C. neoformans, as well as the bacteria E. coli, S. aureus, and methicillin-resistant S. aureus (MRSA; IC50s = 3.94, 0.6, 2.21, 4.55, and 2.21 µg/ml, respectively).2 Emestrin is a chemokine (C-C motif) receptor 2 (CCR2) antagonist (IC50 = 5.4 µM in a radioligand binding assay using isolated human monocytes).3 Emestrin (0.1 µg/ml) induces apoptosis in HL-60 cells.4 It induces heart, thymus, and liver tissue necrosis in mice when administered at doses ranging from 18 to 30 mg/kg.5WARNING This product is not for human or veterinary use.
商品描述
A mycotoxin
分子量
598.6
纯度
≥95%
产品类型
Biochemicals/Antibiotics/Antifungals/Receptor Pharmacology/Antagonists/Toxins/Mycotoxins
背景
别名
Formal_Name:(1R,2R,6aS,20S,21R,22bS)-6a,22b-dihydro-2,16,20-trihydroxy-12-methoxy-25-methyl-2H,8H,20H,22H-1,21-epidithio-21,1-(iminomethano)-9,13:15,19-dimetheno-4,7,14-trioxa-22a-azacyclononadec[cd]azulene-8,22,26-trione
研究领域
Cancer/Cell Death/Apoptosis,Immunology & Inflammation/Innate Immunity,Infectious Disease/Bacterial Diseases/MRSA/Fungal Diseases/Candidiasis,Toxicology & Xenobiotic Metabolism/Organ- & System-Specific Toxicity/Cardiovascular/Hepatotoxicity/Immunotoxicity/Toxic Agents/Toxins
结构式
OC(C=CC([C@@H]([C@]1(SS2)N(C)C([C@]2([C@H](O)C3=COC=CC(OC4=O)[C@]35[H])N5C1=O)=O)O)=C6)=C6OC7=CC4=CC
分子式
C27H22N2O10S2
CAS号
97816-62-1
制备和贮存
保存
≥ 4 years
溶解方法
DMF: soluble
DMSO: soluble
Ethanol: soluble
Methanol: soluble
保存方式
-20°C
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