A 887826 (10 mg)

46919335

Potent voltage-dependent Na_V1.8 channel blocker

480.99

5-(4-Butoxy-3-chlorophenyl)-N-[[2-(4-morpholinyl)-3-pyridinyl]methyl-3-pyridine carboxamide

Potent voltage-dependent Na_V1.8 channel blocker (IC₅₀ = 11 nM in recombinant human Na_V1.8 channels). Reduces tactile allodynia in neuropathic rat models. 3- and 28-fold more potent at Na_V1.8 channels compared to Na_V1.2 and Na_V1.7 channels respectively.

≥97% (HPLC)

Soluble to 50 mM in DMSO

ClC1=C(OCCCC)C=CC(C2=CN=CC(C(NCC3=CC=CN=C3N4CCOCC4)=O)=C2)=C1

C₂₆H₂₉ClN₄O₃

1266212-81-0