全部商品分类
1/2
InVivoMAb anti-human/monkey MDR-1 (CD243)
品牌： BioXcell
下载产品说明书 下载SDS
用小程序，查商品更便捷
收藏
对比
咨询反应种属：
human/monkey
产品介绍
产品介绍
产品信息
克隆号
UIC2
Product Details
The UIC2 monoclonal antibody reacts with an extracellular epitope of human and monkey (African Green) multidrug resistance protein 1 (MDR-1) also known as CD243, P-glycoprotein, and ABCB1. MDR-1 is a 170-180 kDa transmembrane glycoprotein that is expressed by epithelial and endothelial cells, and at low levels by T cells, B cells, NK cells, and hematopoietic stem cells. It is thought to be expressed at high levels by multidrug resistant (MDR) tumor cells. MDR-1 is as an ATP-dependent efflux pump for a large variety of molecules and drugs. This efflux activity has been suggested to lead to resistance to chemotherapy drugs. The UIC2 antibody has been reported to inhibit the efflux of MDR-1 substrates from MDR cells and increase the cytotoxicity of certain drugs in xenogeneic murine tumor models. The UIC2 antibody does not cross-react with mouse MDR-1.Specifications
| Isotype | Mouse IgG2a, κ |
|---|---|
| Recommended Isotype Control(s) | InVivoMAb mouse IgG2a isotype control, unknown specificity |
| Recommended Dilution Buffer | InVivoPure pH 7.0 Dilution Buffer |
| Conjugation | This product is unconjugated. Conjugation is available via our Antibody Conjugation Services. |
| Immunogen | 3T3 fibroblasts transfected with human CD243 cDNA |
| Reported Applications | in vivo MDR-1 blocking/depletion in xenogeneic murine tumor models in vitro MDR-1 blocking Immunohistochemistry (paraffin) |
| Formulation | PBS, pH 7.0 Contains no stabilizers or preservatives |
| Endotoxin | <2EU/mg (<0.002EU/μg) Determined by LAL gel clotting assay |
| Purity | >95% Determined by SDS-PAGE |
| Sterility | 0.2 µm filtration |
| Production | Purified from cell culture supernatant in an animal-free facility |
| Purification | Protein A |
| RRID | AB_2894760 |
| Molecular Weight | 150 kDa |
| Storage | The antibody solution should be stored at the stock concentration at 4°C. Do not freeze. |
组成成分
IGG-免疫球蛋白G型抗体
应用
反应种属
human/monkey
背景
研究领域
Cancer Biology, Immunology
声明 ：本官网所有报价均为常温或者蓝冰运输价格，如有产品需要干冰运输，需另外加收干冰运输费。