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产品信息
商品描述
ABT-510 acetate is an endogenous anti-angiogenic TSP peptide inhibitor, a thrombospondin analog, with anti-inflammatory, anti-cancer and anti-angiogenic activity that induces apoptosis and inhibits ovarian tumor growth in an orthotopic, syngeneic model of epithelial ovarian cancer.ABT-510 acetate reduces angiogenesis and inflammatory responses in a mouse model of inflammatory bowel disease. ABT-510 acetate reduces angiogenesis and inflammation in mouse models of inflammatory bowel disease (IBD) and can be used in cancer research, particularly in epithelial ovarian cancer, as well as in inflammatory bowel disease (IBD).
分子量
1054.28
纯度
95%
可溶性
H2O:90.0 mg/mL (85.4 mM)
In vitro(体外研究)
ABT-510 acetate (1, 5, 10, 20, 50 nM; 24 h) induces apoptosis in ID 8 cells and increases the incidence of apoptosis in human epithelial cancer cell lines SKOV3, OVCAR3, and CAOV3.[1]
ABT-510 acetate (0-10 μM; 7 days) inhibits NO-stimulated growth and invasion of vascular cells into the extracellular matrix. ABT-510 acetate blocks tumor-driven vascular cell growth, NO-driven cGMP flux, and CD36-mediated fatty acid uptake.[3]
In vivo(体内研究)
ABT-510 acetate (100 mg/kg; i.p.; once daily for 90 days) induces apoptosis in vivo and significantly reduces epithelial ovarian tumor size, ascites volume, and secondary lesion spread in mice.[1]
ABT-510 acetate (60 mg/kg; subcutaneous osmotic minipump; once daily for 7 days) reduces angiogenesis and inflammation in a mouse model of inflammatory bowel disease.[2]
背景
分子式
C48H87N13O13
CAS号
442526-87-6
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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