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产品介绍
产品介绍
产品信息
抗原来源
Human
宿主
Mouse
免疫原
Purified recombinant protein fragment corresponding to aa: extra 27-264 from human CHRNA2, expressed in E. coli.
产品用途
Suitable for use in ELISA and Western Blot. Other applications not tested.
简单描述
Nicotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels formed by a pentameric arrangement of alpha and beta subunits to create distinct muscle and neuronal receptors. Neuronal receptors are found throughout the peripheral and central nervous system where they are involved in fast synaptic transmission. This gene encodes an alpha subunit that is widely expressed in the brain. The proposed structure for nAChR subunits is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains a variable cytoplasmic loop, a fourth conserved transmembrane domain and a short C-terminal extracellular region. Mutations in this gene cause autosomal dominant nocturnal frontal lobe epilepsy type 4. Single nucleotide polymorphisms (SNPs) in this gene have been associated with nicotine dependence.
同种型
IgG1
克隆号
7G12H9
克隆类别
Monoclonal
纯度
Purified
形式
Supplied as a liquid in PBS, 0.05% sodium azide.
应用
实验应用
E WB
推荐用量
ELISA: 1:10,000 Western Blot: 1:500-1:2000 Optimal dilutions to be determined by the researcher.
反应种属
Mouse
交叉反应性
Hu Rt
目标/特异性
Recognizes human CHRNA2. Species Crossreactivity: rat
稀释度
ELISA: 1:10,000 Western Blot: 1:500-1:2000 Optimal dilutions to be determined by the researcher.
制备和贮存
保存方式
Storage_Temp:-20°C
Storage_and_Stability:May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. Aliquots are stable for 12 months after receipt. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
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