ACINUS, CT (Apoptotic Chromatin Condensation Inducer in the Nucleus, ACIN1, KIAA0670)

Affinity Purified Purified by immunoaffinity chromatography.

apoptotic chromatin condensation inducer in the nucleus isoform 5

Synthetic peptide corresponding to aa's near the C-terminal of human AcinusL, which are identical to those of mouse Acinus conjugated to KLH.

Chromatin condensation and nuclear fragmentation (CCNF) is the hallmark of apoptosis. CCNF is triggered by the activation of members of caspase family, caspase activated DNase (CAD/DFF40), and several novel proteins including AIF and CIDE. A new inducer of chromatin condensation was recently identified and designated Acinus (for apoptotic chromatin condensation inducer in the nucleus). Acinus is cleaved by caspase-3 and an additional unknown protease generating a small active peptide p17, which causes chromatin condensation in vitro when it is added to purified nuclei. Acinus also induces apoptotic chromatin condensation in cells. Acinus is ubiquitously expressed. Three different spliced forms of Acinus have been identified in human and mouse and designated AcinusL, AcinusS and AcinusS'.

Supplied as a liquid in PBS, 0.02% sodium azide.

Polyclonal

ELISA (EL/EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC)

Human

Anti -ACINUS, CT (Apoptotic Chromatin Condensation Inducer in the Nucleus, ACIN1, KIAA0670)

22985

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