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产品介绍
产品介绍
产品信息
商品描述
Acivicin is an antineoplastic antibiotic believed to act by interfering with glutamine metabolism which has been administered for research in a variety of solid tumors. Bone marrow depression and central neurotoxicity has been observed to suggest that it may be dose-limiting. Acivicin is an irreversible inhibitor of GGT (γ-glutamyl transpeptidase) ID50 = 0.54 mM. Additionally, it inhibits the enzymatic conversion of leukotriene C4 to leukotriene D4 and the bioactivation and release of nitric oxide from GSNO6. Also, the product displays anti tumor and anti-metastatic activity and blocks H. Pylori GGT-induced T-cell inhibition.
分子量
178.57
纯度
≥97%
可溶性
Soluble in water (18 mg/mL, max), and 1 N HCl (50 mg/mL, with heat as needed).
外观
white to beige solid
IC50
HIV-1(RF): IC50 = > 15.2 uM
应用
实验应用
An inhibitor of GGT used for solid tumor research
背景
别名
异恶唑醋酸
分子式
C5H7ClN2O3
CAS号
42228-92-2
沸点
~341.6° C at 760 mmHg (Predicted)
MDL
MFCD00058450
密度
~1.9 g/cm3 (Predicted)
折射率
n20D 1.66
制备和贮存
保存方式
Store at -20° C
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