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产品介绍
产品介绍
产品信息
商品描述
Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of CD13 and Aminopeptidase (leucine aminopeptidase). Actinonin has been observed to inhibit PDF (peptide deformylase), meprin A, and thermolysin. This compound inhibits matrix metalloproteinases (MMP) such as MMP-1, MMP-2, MMP-3, MMP-7, MMP-8, MMP-9, MMP-10, MMP-12, and MMP-13, but not MMP-14. Actinonin also inhibits tumor cell invasion and matrix degradation along with antitumor and apoptosis inducing activity in vitro.
分子量
385.50
纯度
≥98%
可溶性
Soluble in 100% ethanol (20 mg/ml), and DMSO (>20 mg/ml).
外观
Powder
Ki 数据
MMP-1: Ki= 300 nM; MMP-3: Ki= 1700 nM; MMP-8: Ki= 160 nM; MMP-9: Ki= 330 nM; mammalian collagenase: Ki= 14 mM
来源（爱必信）
Synthetic
应用
实验应用
An antibiotic shown to inhibit CD13, MMP-1,2,3,7,8,9,10,12, and MMP-13
背景
分子式
C19H35N3O5
CAS号
13434-13-4
沸点
648.51° C (Predicted)
MDL
MFCD00080257
密度
1.1 g/cm3 (Predicted)
折射率
n20D 1.51
制备和贮存
保存方式
Store at -20° C
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