S-腺苷-L-蛋氨酸

398.44

DMSO : 100 mg/mL (250.98 mM; Need ultrasonic)
H2O : ≥ 43 mg/mL (107.92 mM)

White crystalline powder

Ademetionine (S-adenosylmethionine; SAMe) is a ubiquitous metabolite present in all cells and biological fluids, and serves as a methyl donor in a multitude of different methylation reactions involving proteins, phospholipids, catecholamines and DNA.

SAMe is able to cross the intestinal wall and increase plasma levels. Studies in rats reveal that absorption of the drug is much better after intraduodenal administration compared to oral administration. The systemic bioavailability after oral SAMe administration appears to be low. SAMe dose-dependently (12.5, 25, 50, 100 and 200 mg/kg sc.) decreases immobility time in the forced swimming test in mice and rats. Chronic treatment with SAMe is associated with an increase in density of b-receptors, and a decrease in the affinity of a1 adrenoceptors for phenylephrine in rat cerebral membranes.

A common co-substrate involved in methyl group transfers

S-腺苷-L-蛋氨酸；S-腺苷甲硫氨酸S-Adenosyl-L-methionine; SAMe; AdoMet

C₁₅H₂₂N₆O₅S

29908-03-0