ADRP/Perilipin-2 Recombinant Rabbit mAb (S-2210-3)

Adipose Differentiation-Related Protein (ADRP), also known as Perilipin-2 or ADFP, is a 49 kDa lipid droplet surface protein belonging to the PAT family (which includes Perilipin, ADRP, TIP47, S3-12, and OXPAT). It plays a crucial role in lipid droplet formation, stabilization, and metabolic regulation. ADRP is expressed in various cell types, such as hepatic stellate cells, adipocytes, and macrophages, where it modulates lipid storage and release. Studies show that ADRP promotes intracellular lipid accumulation by inhibiting ATGL (adipose triglyceride lipase)-mediated lipolysis while enhancing exogenous fatty acid uptake, thereby influencing lipid droplet size and secretion. Additionally, dysregulated ADRP expression is associated with pathological conditions, including atherosclerosis, non-alcoholic fatty liver disease (NAFLD), and certain cancers. For example, ADRP is highly expressed in foam cells of atherosclerotic plaques, promoting cholesterol ester accumulation, whereas its expression is reduced in the livers of type 2 diabetic patients with fatty liver disease.