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产品介绍
产品介绍
产品信息
抗原名称
EGFR
商品描述
AG-490 (Tyrphostin B42)是一种EGFR抑制剂，在无细胞试验中IC50为0.1μM，作用于EGFR比作用于ErbB2选择性高135倍，对JAK2也有抑制作用，对Lck，Lyn，Btk，Syk和Src没有抑制活性。
分子量
294.3
纯度
>98%
可溶性
DMSO：58 mg/mL (197.07 mM)
Ethanol：6 mg/mL (20.38 mM)
Ethanol：6 mg/mL (20.38 mM)
外观
yellow solid
In vivo(体内研究)
AG490 significantly inhibits the development of type 1 diabetes (T1D) (p = 0.02, p = 0.005; at two different time points). Monotherapy of newly diagnosed diabetic NOD mice with AG490 (1 mg/mouse) markedly results in disease remission in treated animals (n=23) in comparision to the absolute inability (0%; 0/10, p=0.003, Log-rank test) of DMSO and sustained eugluycemia is maintained for several months following drug withdrawal. AG490 (1-10 µg) significantly attenuates ʎ-carrageenan-induced thermal hyperalgesia in a dose-dependent manner. AG490 also reduces mechanical hyperalgesia.
背景
别名
AG 490; Tyrphostin AG 490; AG490; Zinc02557947;AG-490 (Tyrphostin B42)
分子式
C17H14N2O3
CAS号
133550-30-8
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
参考图片
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