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AGK2
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产品介绍
产品介绍
产品信息
抗原名称
SIRT2
商品描述
AGK2是一个有效的选择性SIRT2抑制剂，IC50值为3.5 μM。
分子量
434.27
纯度
＞98%
可溶性
DMSO : 4.3 mg/mL (10 mM)
外观
yellow
In vitro(体外研究)
In SIRT2-myc-expressing HeLa cells, AGK2 effectively inhibits the activity of SIRT2, and increases acetylated tubulin. AGK2 protects dopaminergic neurons from α-Syn–induced toxicity in primary midbrain cultures. AGK2 induces both necrosis and caspase-3-dependent apoptosis in C6 glioma cells. SIRT2 also decreases merlin-mutant viability of mouse schwann cells (MSCs) without substantially reducing wild-type MSC viability.
In vivo(体内研究)
In drosophila model of parkinson's disease, AGK2 rescues α-Syn–mediated toxicity and modify aggregation.
背景
别名
AGK-2
分子式
C23H13Cl2N3O2
CAS号
304896-28-4
制备和贮存
保存方式
Store at -20℃ for one year（Powder）；Store at 2-4℃ for two weeks；Store at -20℃ for six months after dissolution.
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